Who are the people and organizations radically rethinking our relationship with nature? What can we learn from existing experiments? How do we institutionalise a different relationship with nature? Can and should we be looking for ways to foster interspecies responsibilities? And with biotech pushing the boundaries of what humanity can do in terms of manipulating genetic code, what are the options ahead of us? The latest HDR called for a new ways to understand human development in the Anthropocene: how should our relationship to Nature change if we want to remain within planetary boundaries?